(A Telegraph News Paper Report by G.S.Mathur on 17/02/2013)

DSCN8455Indian and British scientists have established a research centre to probe disease mechanisms and seek out treatment strategies for intractable brain disorders through joins studies never attempted before in India.

The Institute for Stem Cell Biology and Regenerative Medicine (InStem), Bangalore, will house the Centre for Brain Development and Repair to be launched on Saturday (16/02/2013) under a collaborative initiative with the University of Edinburgh.

The centre will start with research on autism spectrum disorders and other conditions that lead to intellectual disabilities, but will expand its activities to cover degenerative brain disorders such as dementia, scientists said.

“We are trying to understand the molecular events in brain cells, and their impacts on brain circuitry, brain chemistry and behaviour”, said Sumantra Chattarji, a neuro biologist at the National Centre for Bilogical Sciences, Bangalore and the director of the new centre.

The launch of the centre follows two years of collaborative research between InStem, the NCBS and University of Edinburgh. “This will pool the capabilities of the high-achieving scientists from these (three) epicenters of brain medicine research to tackle some of the most intractable problems in 9brain) medicine,” Stephen Hillier, a biologist and the vice-president international at the University of Edinburgh told The Telegraph.

In independent studies earlier, the Bangalore and Edinburgh groups have shown that it may be possible to reverse certain neuro-developmental disorders for which there are no standard treatments yet.

Chattarji’s work on laboratory mice three years ago had raised hopes that symptoms of Fragile X Syndrome, the most common cause of inherited mental retardation, maybe reversed through a pharmacological compound.

In Edinburgh, Adrian Bird has – also through studies on mice- suggested that the symptoms of a condition called Rett Syndrome, the most physically disabling of the autism spectrum disorders, may be reversed.

Most of the research in such areas has been focused on trying to pinpoint genes that might be involved in such disorders. At the new centre, scientists will try to interpret how gene variations influence signals between brain cells and how this in turn affects behaviour.

“A major task ahead is to develop rat models to study brain disorders” Chatterji told this newspaper. “Rats can be assigned far more complex tasks than mice and are more suitable animal models to capture brain disorders in humans”.

Scientists expect that a better understanding of the disease mechanisms could lead them to new treatment strategies to correct or reverse the effects of the disease. Rat models will also help scientists evaluate candidate drugs.

The Bangalore centre will collaborate with medical institutions in India and Edinburgh, including the Anne Rowling Regenerative Neurology Clinic, Edinburgh, built through a 10 million pound donation by Harry Potter creator J.K.Rowling, and named after her mother.

“What excites me most is the possibility of working with both PhD students and clinician neurologists (doctors) in India” said Siddharthan Chandran, professor of Neurology at the University of Edinburgh, one of the collaborators.

The centre will try to coax doctors from the Christian Medical College, Vellore, The National Institute of Mental Health and Neurosciences, Bangalore and other medical universities to join its research projects.

“India needs a cadre of clinician-scientists – highly qualified doctors who work with patients and in the laboratory” said Chattarji. “They have a deeper appreciation of the disorders and could also help in evaluating candidate drugs”.

Scientists at the centre are likely to seek research funding from both India and UK government agencies such as India’s department of Biotechnology and the department of Science and Technology or the UK’s Medical Research Council.

DSCN8532 Editors Note: Dr Sumantra Chatterjee (Sona- son of Lt Dipankar Chatterjee, Prof. Physics Department, Siksha Bhavana)  passed out from Patha Bhavan in later half of 1970s. A major in Physics, Sumantra shifted to Bio-Physics and ultimately to Neuro Science. He is the leading neuro scientist of India, engaged in many interesting and path breaking studies on human brain. Sorry, for the rather crazy profile pictures of Sona, as these are all I have, photographed when he visited the annual Poush Mela.

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  1. Shubhashis says:

    I had a small chat with Sumantra Chatterjee (Sona), maybe two years back over breakfast at his home at Purvapally Santiniketan. The conversation ultimately led to the topic of hypertension.
    Usually someone suffering with hypertension is administered drugs which basically slow down the nervous system, to reduce the effect of hypertension to some extent.

    Sona explained to me the exact neurological state in hypertension. In a normal brain the several neurons among themselves create a steady circuit in which normal inputs are processed and transmitted, its like a complex but very efficient chain of electrical circuits.

    In hypertension state extra neurons surface within the brain, creating extra electrical loops and sub-loops within the erstwhile stable circuitry of the brain. As a result the information and processing traffic gets haywire; i.e. a general disruption occurs within the brain due to those extra electrical loops.

    In this condition the ideal treatment for hypertension would be to prevent the extra neurons to erupt within the brain. Sona’s finding regarding hypertension has already prompted the drug manufacturing companies to develop medicines to prevent the creation of extra neurons. The actual medicine may surface a decade later after all necessary trials and etc are completed.

    This is just to highlight the importance of the study conducted on brain circuitry by Sumantra and his team.

  2. Tapas Basu says:

    I myself a patient of both Advanced Diabetes, Hypertension with Renal Involvement.

    Hypertension is dependent on many thing- Adreno-Cotical axis, Hormonal Imbalance including that of Renin Mechanism, Electrolyte balance, Thyroid profile among many other factors.

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